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PEGS Europe

Presentation Abstract

Wednesday November 7, 15.05

Presenter: Dr Anne Goupil-Lamy, Principal Scientist

Novel in silico Prediction Algorithms for the Design of Stable Biologics

Understanding the effects of mutation on protein stability and protein binding affinity is an important component of successful protein design, especially in the area of protein therapeutics.  In silico approaches to predict the effects of amino acid mutations can be used to guide experimental design and help reduce the cost of bringing therapeutics to market.   We have implemented and validated several novel methods for fast computational mutagenesis of proteins to calculate the energy effect of mutation on protein stability, and on protein-protein binding affinity with an optional pH dependency calculation. We will present those methods and applications to antibody design.

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