Process Production Operations

Empowering production operations in process industries to shorten time to market and maximize profitability by leveraging process and quality data

Genealogy Mapping

BIOVIA’s interactive Process Genealogy Mapping is a purpose-built, validated capability for visualizing all the points where splitting and pooling occur in the process stream during production operations. By clicking on the map, users can easily see all the input and output relationships in the process stream from the start to the end of the process as they relate to any unit operation.

Interactive BIOVIA Discoverant Genealogy Map

Automated calculation of the fractional contributions of upstream operations into downstream operations enables users to do meaningful upstream/downstream correlation analysis for Quality-by-Design (QbD).

Diagram showing a process with splitting and pooling of the process stream where users would like to correlate variation in Process Step 1 with the Process outcome

An important benefit of being able to easily perform upstream /downstream correlations in complex manufacturing processes is that significant barriers are removed from identifying potential cause-and-effect relationships between upstream process conditions and downstream process outcomes. Such relationships drive the formation of hypotheses that can be confirmed, extended or refuted using mechanistic knowledge and experimentation. The information thus gained about the relationships between upstream process parameters and downstream process outcomes helps to make processes better understood and outcomes more predictable by linking Critical Process Parameters (CPPs) with Critical Quality Attributes (CQAs) to shape useful process models that meet the goals of QbD.

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